منابع مشابه
Miniaturization of Drug Solubility and Dissolution Testings
Solubility and drug dissolution are of crucial importance for drug formulations. Poor water-solubility of drug candidates is a major obstacle in drug development, since the oral route is the most patient convenient and cost effective way to deliver drugs. In some cases the low aqueous solubility may limit the bioavailability when the absorption of the drug is dissolution limited. About 40% of t...
متن کاملFormulation and Evaluation of Self microemulsifying drug delivery system of low solubility drug for enhanced solubility and dissolution
Atorvastatin is a BCS class II lipid lowering agent. It is insoluble in aqueous solution of pH 4 and below; it is very slightly soluble in water and pH 7.4 phosphate buffer. In the present investigation an attempt has been made to enhance solubility and dissolution of poorly soluble drug by formulating self microemulsifying drug delivery system (SMEDDS). The solubility of atorvastatin in indivi...
متن کاملSolubility and Dissolution Enhancement: An overview
Poorly water soluble compounds have solubility and dissolution related bioavailability problems. The dissolution rate is directly proportional to solubility of drugs. Drugs with low aqueous solubility have low dissolution rates and hence suffer from oral bioavailability problems. The poor solubility and poor dissolution rate of poorly water soluble drugs in the aqueous gastro intestinal fluids ...
متن کاملComparative Evaluation of Different Carriers to Enhance Solubility and Dissolution of Poor Water Soluble Drug
The aim of this study was to investigate the effect of different carriers on solubility and in vitro dissolution of poorly water soluble drug meloxicam (MLX). Solid dispersions with Polyethylene glycol-6000 (PEG6000), Poloxamer 188 (Plx188), Poloxamer 407 (Plx407) and inclusion complexes (ICs) with β cyclodextrin (β-CD) were prepared by different methods in three different weight ratios. All SD...
متن کاملDrug Nanocrystals: Theoretical Background of Solubility Increase and Dissolution Rate Enhancement
Regardless of the administration route, the key factor for the success and reliability of any formulation is drug bioavailability, defined as the rate and extent at which the active drug is absorbed from a pharmaceutical form and becomes available at the site of drug action.1 Although metabolism and physiological factors highly affect drug absorption by living tissues, bioavailability is strong...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutical and Life Sciences
سال: 2013
ISSN: 2305-0330
DOI: 10.3329/ijpls.v2i1.15133